Non-Cell Autonomous Effects of the Senescence-Associated Secretory Phenotype in Cancer Therapy

Non-Cell Autonomous Effects of the Senescence-Associated Secretory Phenotype in Cancer Therapy

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In addition to promoting various forms of cell death, most conventional anti-tumor therapies also promote senescence.There is now extensive evidence that therapy-induced senescence (TIS) might be transient, raising the concern that Heat Therapy Pack TIS could represent an undesirable outcome of therapy by providing a mechanism for tumor dormancy and eventual disease recurrence.The senescence-associated secretory phenotype (SASP) is a hallmark of TIS and may contribute to aberrant effects of cancer therapy.Here, we propose that the SASP may also serve as a major driver of escape from senescence and the re-emergence of proliferating tumor cells, wherein factors secreted from the senescent cells contribute to the restoration of tumor growth in a non-cell autonomous fashion.Accordingly, anti-SASP therapies might serve to mitigate the deleterious outcomes of TIS.

In addition to providing an overview BOSCH KIV86VSF0GB BUILT IN 60/40 Fridge Freezer of the putative actions of the SASP, we discuss recent efforts to identify and eliminate senescent tumor cells.